- Written by
Jim Knaub
- Posted November 2, 2009 at 12:14 pm
A first-of-its-kind study on radiation therapy after melanoma surgery reports a significantly lower recurrence rate in high-risk patients who received radiation therapy to the surgery site after having their melanomas removed.
The study, presented today at the 51st Annual Meeting of the American Society for Radiation Oncology in Chicago, found, high-risk melanoma patients who are treated with radiation after surgery have a 19% risk of their cancer returning to the lymph nodes compared a 31% risk to those patients who do not have radiation therapy. Click here for the study abstract.
“Results of this trial now confirm the place of radiation therapy in the management of patients who have high risk features following surgery for melanoma involving the lymph nodes,” said Bryan Burmeister, MD, lead author of the study and a radiation oncologist at Princess Alexandra Hospital in Brisbane, Australia. “In some institutions, radiation treatment is routine protocol, while in others, the protocol has been either for patients to just be observed, or receive some type of adjuvant chemotherapy or immunotherapy. I encourage patients with melanoma to talk to their doctors about whether radiation should be added to their treatment plan.”
When melanoma has spread from its original site to the lymph nodes, treatment typically involves surgically removing cancerous and the remaining lymph nodes in that region, a surgery called a lymphadenectomy. This multicenter, randomized trial examined the effects of external beam radiation treatment after surgery for melanoma patients who had a high risk of the cancer returning to the lymph nodes.
From March 2002 to September 2007, 217 patients from 16 cancer centers who had undergone a lymphadenectomy for melanoma cancer were randomized to receive radiation treatment within 12 weeks after surgery or be observed, with a median follow-up of 27 months. Results of the study show there was significant improvement in the control of regional recurrence among patients who underwent radiation therapy, compared to the observation group.
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